Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4614
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: mscL PA4614
Status: annotated
Amino acids: 137
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381 Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. GO:0034220 A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.377

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0008381 Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress.
GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
GO:0034220 A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
13	26	ProSitePatterns	PS01327	Large-conductance mechanosensitive channels mscL family signature.
13	26	InterPro	IPR019823	Large-conductance mechanosensitive channel, conserved site
78	96	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	136	PANTHER	PTHR30266	MECHANOSENSITIVE CHANNEL MSCL
3	136	InterPro	IPR037673	Large-conductance mechanosensitive channel/anditomin synthesis protein L
1	77	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97	137	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
84	92	PRINTS	PR01264	Bacterial mechano-sensitive ion channel signature
84	92	InterPro	IPR001185	Large-conductance mechanosensitive channel
6	20	PRINTS	PR01264	Bacterial mechano-sensitive ion channel signature
6	20	InterPro	IPR001185	Large-conductance mechanosensitive channel
93	102	PRINTS	PR01264	Bacterial mechano-sensitive ion channel signature
93	102	InterPro	IPR001185	Large-conductance mechanosensitive channel
3	134	FunFam	G3DSA:1.10.1200.120:FF:000001	Large-conductance mechanosensitive channel
3	134	Gene3D	G3DSA:1.10.1200.120	-
3	134	InterPro	IPR036019	Large-conductance mechanosensitive channel MscL
13	127	SUPERFAMILY	SSF81330	Gated mechanosensitive channel
13	127	InterPro	IPR036019	Large-conductance mechanosensitive channel MscL
3	132	Hamap	MF_00115	Large-conductance mechanosensitive channel [mscL].
3	132	InterPro	IPR001185	Large-conductance mechanosensitive channel
71	93	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
20	42	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	133	NCBIfam	TIGR00220	large conductance mechanosensitive channel protein MscL
4	133	InterPro	IPR001185	Large-conductance mechanosensitive channel
3	131	Pfam	PF01741	Large-conductance mechanosensitive channel, MscL
3	131	InterPro	IPR037673	Large-conductance mechanosensitive channel/anditomin synthesis protein L

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4614	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.377

PA4614