Protein profile

PA4617

hypothetical protein

Genome: NC_002516.2

Gene: PA4617 rlmG Structure source: AlphaFold UniProt Q9HVH4
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Amino acids 374
Annotations 10
Features 18
PDB binders 0
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
PA4617
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4617 rlmG
Status
annotated
Amino acids
374
Structure source
AlphaFold
EC
2.1.1.174
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0052916 Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine. GO:0003676 Binding to a nucleic acid. GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPLFATPFAQLDLVRQPEQDGEPLQAFDAADEYLLNQLHERGVTAQCRVLVLNDAFGALAASLAPHVQVTSSGDSHLGFLALRKNLARNGLDLGSVRFVPASETAVGPFDHVLVKVPKTLALLEEQLIRLHGQLAPGAQVVAAGMVKHLPRAAGDLLERYIGPMHASLAVKKARLLIAEAAERPQPRSPYPTRYRLEQPPLTLLNHANVFCREGLDIGTRAFLPHLPRSLGALRAADLGCGNGVLGIAYALLNPQAELALVDESYMAVQSARENWRAALGERPATFRADDGLAGQAAGSLDLVLCNPPFHQQQVVGDFLAWRMFLQARDALAAGGELWIVGNRHLGYHAKLKRLFRGVEQVAANPKFVILKAGK

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0052916 Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.
  • GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0031167 The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 374 PIRSF PIRSF037565 RRNA_m2G_Mtase_RsmD
1 374 InterPro IPR017237 rRNA (guanine-N2-)-methyltransferase, RlmG
27 374 PANTHER PTHR47816 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C
27 374 InterPro IPR046977 rRNA (guanine-N(2)-)-methyltransferase RsmC/RlmG
43 161 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
43 161 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
1 374 Hamap MF_01859 Ribosomal RNA large subunit methyltransferase G [rlmG].
201 371 Pfam PF05175 Methyltransferase small domain
201 371 InterPro IPR007848 Methyltransferase small domain
234 340 CDD cd02440 AdoMet_MTases
8 183 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
8 183 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
303 309 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature.
303 309 InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
199 356 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
199 356 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
188 374 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
188 374 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4617
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.745