Protein profile

PA4618

hypothetical protein

Genome: NC_002516.2

Gene: PA4618 Structure source: AlphaFold UniProt Q9HVH3

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Amino acids 323

Annotations 1

Features 6

PDB binders 0

Druggability 0.753

Overview

Basic information about this protein and its source genome.

Accession: PA4618
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4618
Status: annotated
Amino acids: 323
Structure source: AlphaFold

GO:0043546 Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MQHLDLQVVRKALKWSVGGERVWFCTVLTTYGSAPRAPGSLLAVNASGEWIGSLSGGCVEDDFLERVAAGGFPDPAVIVRYGEGDDPNSNIRLPCGGILDVLVENLAPDCDVQAHLRELESALLGQRRLLREVELGSGARSLRDDSSHGPRAERDGECVRLRVGAAQRLLLAGYSSVAHACAEFGKGLGFEVILCDPREEALRGVVLEGIEIRRELPSLFIADGGCHADTAVVALTHDPKIDDLAMLEAVRTEAFYIGVMGSRATSEKRFERLRRIGGLGDAELARIHAPIGLNLGSKTPAEIALAVLADILRIRNGIPRERL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0043546 Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
19	69	Pfam	PF02625	XdhC and CoxI family
19	69	InterPro	IPR003777	XdhC- CoxI
168	321	Gene3D	G3DSA:3.40.50.720	-
7	321	PANTHER	PTHR30388	ALDEHYDE OXIDOREDUCTASE MOLYBDENUM COFACTOR ASSEMBLY PROTEIN
169	311	Pfam	PF13478	XdhC Rossmann domain
169	311	InterPro	IPR027051	XdhC Rossmann domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4618	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.753