Protein profile

PA4619

cytochrome C

Genome: NC_002516.2

Gene: PA4619 Structure source: AlphaFold UniProt Q9HVH2
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Amino acids 415
Annotations 5
Features 36
PDB binders 0
Druggability 0.896

Overview

Basic information about this protein and its source genome.

Accession
PA4619
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4619
Status
annotated
Amino acids
415
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506 Binding to an iron (Fe) ion. GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.896
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records
Show feature table
Start End DB Term Name
30 129 Pfam PF00034 Cytochrome c
30 129 InterPro IPR009056 Cytochrome c-like domain
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
297 387 ProSiteProfiles PS51007 Cytochrome c family profile.
297 387 InterPro IPR009056 Cytochrome c-like domain
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
28 131 ProSiteProfiles PS51007 Cytochrome c family profile.
28 131 InterPro IPR009056 Cytochrome c-like domain
1 415 PIRSF PIRSF000018 Mb_ADH_cytochrome_c
1 415 InterPro IPR014353 Membrane-bound alcohol dehydrogenase, cytochrome c subunit
176 289 SUPERFAMILY SSF46626 Cytochrome c
176 289 InterPro IPR036909 Cytochrome c-like domain superfamily
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
17 152 SUPERFAMILY SSF46626 Cytochrome c
17 152 InterPro IPR036909 Cytochrome c-like domain superfamily
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
300 383 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III
300 383 InterPro IPR009056 Cytochrome c-like domain
16 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
308 319 PRINTS PR00605 Class IC cytochrome C signature
308 319 InterPro IPR008168 Cytochrome c, class IC
361 383 PRINTS PR00605 Class IC cytochrome C signature
361 383 InterPro IPR008168 Cytochrome c, class IC
283 414 Gene3D G3DSA:1.10.760.10 -
283 414 InterPro IPR036909 Cytochrome c-like domain superfamily
28 415 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
173 280 ProSiteProfiles PS51007 Cytochrome c family profile.
173 280 InterPro IPR009056 Cytochrome c-like domain
300 404 SUPERFAMILY SSF46626 Cytochrome c
300 404 InterPro IPR036909 Cytochrome c-like domain superfamily
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
4 136 Gene3D G3DSA:1.10.760.10 -
4 136 InterPro IPR036909 Cytochrome c-like domain superfamily
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 406 PANTHER PTHR35008 BLL4482 PROTEIN-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4619
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.896
2 0.218