Amino acids
2154
Annotations
3
Features
60
PDB binders
0
Druggability
0.759
Overview
Basic information about this protein and its source genome.
- Accession
- PA4625
- Gene
- PA4625
- Status
- annotated
- Amino acids
- 2154
- Structure source
- AlphaFold
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO:0098046 A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc).
GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Extracellular
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.759
Sequence
Primary amino-acid sequence viewer.
MVRPDSQRGKRTSSKAGREGRFVLAASSTLMFAIASINAAMAAPTGAQFNPNEIKISQQGKTTLIDQSTQRAIINWKGFDVSADEAVRFNQPGVTSSTLNRVTAGQESVIAGRISAPGQVIIYNSNGVVFSGSAKVDVGSLITTTANISDEHFRQGKLIFDQPGNPDARIVNDGSISVAEKGLAAFVAPSVANNGVINARLGTVAMAAGNAATIDLYGDGLVSIAVTDPVTRKPQDAQALVSNGGAIQADGGSVLITAEQASRVVDNAVNLSGVILARGTEVREGSVALVSKSGDIQIAGKIDVSGPKNGGDVLVSGQQVALASTASIDARGTAQGGSVRIGGDFQGRGELPRAKNATLAKGASIDVSATGKGNGGLAVVWSDGNTRMDGRILARGGAQGGNGGLVETSGKVNLSIADSAYVSVAAPYGNGGTWLLDPTTLRIVASGGTSGSVGGANGASGDATVNASVVTGALAGGKVTLSASDRLSVEAPLITSNLGGASRGLELIATGPAGAVDISAPILFRNGSLAIRAGGNINFLSGGTPQTSGIVDLGSGTLWMQTSTAGKISQQAGTALIAANLAGRAGSIDLASWDNYAGNLALQTFNGTLKYRQSNATGVTTSGTVFDPFINQSMTGTAQNIVSSVGTRILEANSVGTTGNYTLTADGNSEFDRLVFTALPYRRVSGSASFPTNDSSDYLVTNLRYQVNGSNVTATPNGGAPSGFTVAAGNGSVTTWTGNWGTSWGVKGFGGVIGVTDELQYDVGTGLTEELIFGLGGKTSRVDTRLDLFMREGAFNSFAERAQVEMFKTTTTAGDILSRQQTATLTANDATRVYGDVNPTLTATMSGINAIDAYVNSQFNDLYQATASTTATQASNVGQYAITGNANGSEYFSQRYQLVRQDGRLTVTPAQLIVSADAKTKVYGDADPTLTYQVSGLKNSDTAAGVLSGNLGRVAGENVGNYGILQGGLGLNTANYTLSYVGNDLRITPAQLNVIADAKTKVYGDLDPALTYQVSGLKRGDTAGAVLNGGSLSRVAGENVGVYGINQGGLGLVSSNYTLNYQGNNLTITKALLNVIADAKTKVYGDADPALTYQVSGLKNGDTAGAVLNGGSLSRVAGENVGVYGINQGGLGLLSANYDLSYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGSILTGGLNRAAGENVGVYGINQGDLALNSGNYDLSYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGGLVRVSGENVGNYAIQQGGLGLVSGNYDLAYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDSAGSILTGGLNRAAGENVGVYGINQGDLALNSGNYDLSYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGGLVRVSGENVGNYAIQQGGLGLVSGNYDLAYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGSLSRVAGENVGVYGINQGDLALNSGNYDLSYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGGLVRVSGENVGNYAIQQGGLGLVSGNYDLAYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDSAGSILTGGLNRAAGENVGVYGINQGDLALNSGNYDLSYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGGLVRVSGENVGNYAIQQGGLGLVSGNYDLAYQGNNLTITKALLNVIADAKTKVYGDADPSLTYQVSGLKNGDTAGAVLNGGSLSRVAGENVGVYGINQGGLGLVSGNYDLAYQGNNLTITKALLNVIADGKTKVYGDADPSLTYQVSGLKNGDSAGSILTGGLNRDAGENVGVYGINQGGLVLTSGNYDLAYQGNDLTITKALLNVFADAKSKQVGTADPALTYQVSGLKNGDSAGQVLAGGLGRVGGEAVGQYDILQGGLALTSGNYQLNYQGNLLSILPLPVTPGDLGQLAALSDLRELQKGRDPDTPGDAVYRTTTLENPFLENPFLRAYALGMDVSDPNLLPATAAGPAEDASAKRVGQFTDRPLRAEAESGAGCSNQSYLADYWSCFNKPLNF
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
3 GO
Gene Ontology (GO)
3- GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
- GO:0098046 A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc).
- GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
Sequence Features
Domain/signature hits from InterPro and related databases.
60 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 42 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 1 | 22 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 63 | 336 | SUPERFAMILY | SSF51126 | Pectin lyase-like |
| 63 | 336 | InterPro | IPR011050 | Pectin lyase fold/virulence factor |
| 42 | 424 | Gene3D | G3DSA:2.160.20.10 | - |
| 42 | 424 | InterPro | IPR012334 | Pectin lyase fold |
| 40 | 152 | SMART | SM00912 | Haemagg_act_2a |
| 40 | 152 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 1691 | 1857 | PANTHER | PTHR12338 | AUTOTRANSPORTER |
| 42 | 437 | FunFam | G3DSA:2.160.20.10:FF:000109 | Hemagglutination activity domain protein |
| 74 | 149 | NCBIfam | TIGR01901 | filamentous hemagglutinin family N-terminal domain |
| 74 | 149 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 1534 | 1612 | Gene3D | G3DSA:3.30.160.710 | - |
| 1695 | 1773 | Gene3D | G3DSA:3.30.160.710 | - |
| 1372 | 1450 | Gene3D | G3DSA:3.30.160.710 | - |
| 1776 | 1847 | Gene3D | G3DSA:3.30.160.710 | - |
| 893 | 954 | Gene3D | G3DSA:3.30.160.710 | - |
| 1131 | 1197 | Gene3D | G3DSA:3.30.160.710 | - |
| 796 | 886 | Gene3D | G3DSA:3.30.160.710 | - |
| 1453 | 1525 | Gene3D | G3DSA:3.30.160.710 | - |
| 1211 | 1289 | Gene3D | G3DSA:3.30.160.710 | - |
| 1050 | 1121 | Gene3D | G3DSA:3.30.160.710 | - |
| 1718 | 1793 | Pfam | PF18676 | MBG domain (YGX type) |
| 1718 | 1793 | InterPro | IPR041286 | MBG domain, YGX type |
| 912 | 985 | Pfam | PF18676 | MBG domain (YGX type) |
| 912 | 985 | InterPro | IPR041286 | MBG domain, YGX type |
| 1476 | 1551 | Pfam | PF18676 | MBG domain (YGX type) |
| 1476 | 1551 | InterPro | IPR041286 | MBG domain, YGX type |
| 992 | 1067 | Pfam | PF18676 | MBG domain (YGX type) |
| 992 | 1067 | InterPro | IPR041286 | MBG domain, YGX type |
| 1234 | 1309 | Pfam | PF18676 | MBG domain (YGX type) |
| 1234 | 1309 | InterPro | IPR041286 | MBG domain, YGX type |
| 1154 | 1228 | Pfam | PF18676 | MBG domain (YGX type) |
| 1154 | 1228 | InterPro | IPR041286 | MBG domain, YGX type |
| 1960 | 2033 | Pfam | PF18676 | MBG domain (YGX type) |
| 1960 | 2033 | InterPro | IPR041286 | MBG domain, YGX type |
| 1799 | 1874 | Pfam | PF18676 | MBG domain (YGX type) |
| 1799 | 1874 | InterPro | IPR041286 | MBG domain, YGX type |
| 1638 | 1712 | Pfam | PF18676 | MBG domain (YGX type) |
| 1638 | 1712 | InterPro | IPR041286 | MBG domain, YGX type |
| 1073 | 1148 | Pfam | PF18676 | MBG domain (YGX type) |
| 1073 | 1148 | InterPro | IPR041286 | MBG domain, YGX type |
| 1557 | 1632 | Pfam | PF18676 | MBG domain (YGX type) |
| 1557 | 1632 | InterPro | IPR041286 | MBG domain, YGX type |
| 1880 | 1954 | Pfam | PF18676 | MBG domain (YGX type) |
| 1880 | 1954 | InterPro | IPR041286 | MBG domain, YGX type |
| 1395 | 1470 | Pfam | PF18676 | MBG domain (YGX type) |
| 1395 | 1470 | InterPro | IPR041286 | MBG domain, YGX type |
| 1315 | 1389 | Pfam | PF18676 | MBG domain (YGX type) |
| 1315 | 1389 | InterPro | IPR041286 | MBG domain, YGX type |
| 824 | 906 | Pfam | PF18676 | MBG domain (YGX type) |
| 824 | 906 | InterPro | IPR041286 | MBG domain, YGX type |
| 1 | 42 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM |
| 35 | 42 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 23 | 34 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 21 | 43 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 40 | 303 | Pfam | PF05860 | TPS secretion domain |
| 40 | 303 | InterPro | IPR008638 | Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain |
| 43 | 2154 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 42 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA4625
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 2 | 0.759 |