Protein profile

PA4627

16S rRNA methyltransferase

Genome: NC_002516.2

Gene: rsmC PA4627 Structure source: AlphaFold UniProt Q9HVG4
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Amino acids 332
Annotations 11
Features 17
PDB binders 0
Druggability 0.744

Overview

Basic information about this protein and its source genome.

Accession
PA4627
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
rsmC PA4627
Status
annotated
Amino acids
332
Structure source
AlphaFold
EC
2.1.1.172
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0052914 Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine. GO:0003676 Binding to a nucleic acid. GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.744
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDPRSEVLLRQRHLFATPLLLAGLPADDLLAELPQAQGWSWHAGEQAQLDARFPGRSRFDTRAPTGAWTSAVLFLPKSRELTDYLLASLAARLPGGELFLVGEKRGGIERASKQLAAYGKPRKLDSARHCQLWQVRIEQAPAEPDLHALAQRYSLPLADGELQVVSLPGVFSHGRLDRGSALLLGQLQALPGGHLLDFGCGAGVLGAVLKRRYPASRLSLLDVDAFAVESSRLTLAANGLDGEVIAADGIDGAPRELAAIVSNPPFHQGVHTDYQASERLLQRAAEHLAPGGELRLVANSFLKYPPLIERHLGPCRTLAEGDGFRIYSARRS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 10 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

10
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0052914 Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.
  • GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008649 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
195 294 CDD cd02440 AdoMet_MTases
5 153 Pfam PF08468 Methyltransferase small domain N-terminal
5 153 InterPro IPR013675 Methyltransferase small, N-terminal
260 266 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature.
260 266 InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
93 306 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
93 306 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
1 331 PANTHER PTHR47816 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE C
1 331 InterPro IPR046977 rRNA (guanine-N(2)-)-methyltransferase RsmC/RlmG
1 331 Hamap MF_01862 Ribosomal RNA small subunit methyltransferase C [rsmC].
1 331 InterPro IPR023543 rRNA small subunit methyltransferase C
149 332 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
149 332 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
1 144 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
1 144 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
161 327 Pfam PF05175 Methyltransferase small domain
161 327 InterPro IPR007848 Methyltransferase small domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4627
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.744