Protein profile

PA4630

hypothetical protein

Genome: NC_002516.2

Gene: PA4630 Structure source: AlphaFold UniProt Q9HVG1
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Amino acids 147
Annotations 1
Features 9
PDB binders 0
Druggability 0.854

Overview

Basic information about this protein and its source genome.

Accession
PA4630
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4630
Status
annotated
Amino acids
147
Structure source
AlphaFold
GO
GO:0030638 The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.854
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030638 The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
15 134 Pfam PF07366 SnoaL-like polyketide cyclase
15 134 InterPro IPR009959 Polyketide cyclase SnoaL-like
7 135 NCBIfam TIGR02096 ketosteroid isomerase-related protein
7 135 InterPro IPR011721 Conserved hypothetical protein CHP02096
4 143 Gene3D G3DSA:3.10.450.50 -
3 141 PANTHER PTHR38436 POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN
3 141 InterPro IPR009959 Polyketide cyclase SnoaL-like
3 142 SUPERFAMILY SSF54427 NTF2-like
3 142 InterPro IPR032710 NTF2-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4630
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.854
2 0.826