Protein profile

PA4631

hypothetical protein

Genome: NC_002516.2

Gene: PA4631 Structure source: Experimental + AlphaFold UniProt Q9HVG0
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Amino acids 341
Annotations 2
Features 6
PDB binders 0
Druggability 0.885

Overview

Basic information about this protein and its source genome.

Accession
PA4631
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4631
Status
annotated
Amino acids
341
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029 Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.885
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004029 Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
17 237 Pfam PF01370 NAD dependent epimerase/dehydratase family
17 237 InterPro IPR001509 NAD-dependent epimerase/dehydratase
15 338 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
15 338 InterPro IPR036291 NAD(P)-binding domain superfamily
1 341 Gene3D G3DSA:3.40.50.720 -
13 335 PANTHER PTHR48079 PROTEIN YEEZ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2X4G
X-ray 2.65 Å A
100.0% 1-341
PDBe RCSB PDBj File
Viewing
AlphaFold PA4631
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.885
5 0.631
2 0.339

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.7 0.206
2 2.7 0.08
3 1.65 0.027
4 0.91 0.004