Protein profile

PA4633

chemotaxis transducer

Genome: NC_002516.2

Gene: PA4633 Structure source: Experimental + AlphaFold UniProt Q9HVF8
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Amino acids 712
Annotations 5
Features 28
PDB binders 0
Druggability 0.766

Overview

Basic information about this protein and its source genome.

Accession
PA4633
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4633
Status
annotated
Amino acids
712
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.766
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
70 238 CDD cd12913 PDC1_MCP_like
14 711 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
381 712 Gene3D G3DSA:1.10.287.950 -
450 711 SMART SM00283 MA_2
450 711 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
94 236 Gene3D G3DSA:3.30.450.20 PAS domain
382 712 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
32 362 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
363 384 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
10 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
381 435 SMART SM00304 HAMP_11
381 435 InterPro IPR003660 HAMP domain
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
440 676 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
440 676 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
403 712 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
689 709 Coils Coil Coil
385 712 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
381 435 ProSiteProfiles PS50885 HAMP domain profile.
584 604 Coils Coil Coil
385 430 CDD cd06225 HAMP
495 678 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
495 678 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
477 675 CDD cd11386 MCP_signal
362 384 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 31 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
380 431 Pfam PF00672 HAMP domain
380 431 InterPro IPR003660 HAMP domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7PRR
X-ray 1.80 Å A,B
46.3% 32-361
PDBe RCSB PDBj File
Viewing
PDB 7PRQ
X-ray 2.00 Å A,B
46.3% 32-361
PDBe RCSB PDBj File
Loaded
AlphaFold PA4633
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.766
2 0.309

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.0 0.425
2 1.59 0.025
3 1.55 0.024
4 0.94 0.005