Protein profile

PA4635

hypothetical protein

Genome: NC_002516.2

Gene: PA4635 Structure source: AlphaFold UniProt Q9HVF6
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Amino acids 234
Annotations 2
Features 28
PDB binders 0
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
PA4635
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4635
Status
annotated
Amino acids
234
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
57 62 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
63 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
63 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 50 PRINTS PR01837 MgtC/SapB protein signature
32 50 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
59 81 PRINTS PR01837 MgtC/SapB protein signature
59 81 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
13 32 PRINTS PR01837 MgtC/SapB protein signature
13 32 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
86 110 PRINTS PR01837 MgtC/SapB protein signature
86 110 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
4 228 PANTHER PTHR33778 PROTEIN MGTC
4 228 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
37 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
128 234 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 232 Gene3D G3DSA:3.30.70.260 -
22 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 131 Pfam PF02308 MgtC family
11 131 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
81 99 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
95 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 56 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4635
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.843
2 0.601