Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4652
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4652
Status: annotated
Amino acids: 790
Structure source: AlphaFold

GO

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.887

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
1	27	Phobius	SIGNAL_PEPTIDE	Signal peptide region
28	790	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	27	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	13	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	27	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
282	292	ProSitePatterns	PS01151	Fimbrial biogenesis outer membrane usher protein signature.
282	292	InterPro	IPR018030	Fimbrial membrane usher, conserved site
611	701	Gene3D	G3DSA:2.60.40.2610	Outer membrane usher protein FimD, plug domain
611	701	InterPro	IPR042186	Outer membrane usher protein FimD, plug domain
240	329	Gene3D	G3DSA:2.60.40.3110	-
707	783	Gene3D	G3DSA:2.60.40.2070	-
707	783	InterPro	IPR043142	PapC-like, C-terminal domain superfamily
707	768	Pfam	PF13953	PapC C-terminal domain
707	768	InterPro	IPR025949	PapC-like, C-terminal domain
14	22	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
49	782	PANTHER	PTHR30451	OUTER MEMBRANE USHER PROTEIN
49	782	InterPro	IPR000015	Outer membrane usher protein
23	27	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
266	691	Pfam	PF00577	Outer membrane usher protein
266	691	InterPro	IPR000015	Outer membrane usher protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4652	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.887
12				0.573
32				0.302
16				0.22

PA4652