Protein profile

PA4662

glutamate racemase

Genome: NC_002516.2

Gene: murI PA4662 Structure source: AlphaFold UniProt Q9HVD0
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Amino acids 265
Annotations 8
Features 20
PDB binders 3
Druggability 0.864

Overview

Basic information about this protein and its source genome.

Accession
PA4662
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
murI PA4662
Status
annotated
Amino acids
265
Structure source
AlphaFold
EC
5.1.1.3
GO
GO:0008881 Catalysis of the reaction: L-glutamate = D-glutamate. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008360 Any process that modulates the surface configuration of a cell. GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0016855 Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.864
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0008881 Catalysis of the reaction: L-glutamate = D-glutamate.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0008360 Any process that modulates the surface configuration of a cell.
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0016855 Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
  • GO:0036361 OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
8 246 NCBIfam TIGR00067 glutamate racemase
8 246 InterPro IPR004391 Glutamate racemase
5 223 PANTHER PTHR21198 GLUTAMATE RACEMASE
8 250 Gene3D G3DSA:3.40.50.1860 -
8 250 InterPro IPR001920 Asp/Glu racemase
98 209 Gene3D G3DSA:3.40.50.1860 -
98 209 InterPro IPR001920 Asp/Glu racemase
8 109 SUPERFAMILY SSF53681 Aspartate/glutamate racemase
8 109 InterPro IPR001920 Asp/Glu racemase
182 192 ProSitePatterns PS00924 Aspartate and glutamate racemases signature 2.
182 192 InterPro IPR033134 Asp/Glu racemase, active site 2
7 129 FunFam G3DSA:3.40.50.1860:FF:000002 Glutamate racemase
6 257 Hamap MF_00258 Glutamate racemase [murI].
6 257 InterPro IPR004391 Glutamate racemase
19 217 Pfam PF01177 Asp/Glu/Hydantoin racemase
19 217 InterPro IPR015942 Asp/Glu/hydantoin racemase
72 80 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1.
72 80 InterPro IPR018187 Asp/Glu racemase, active site 1
111 257 SUPERFAMILY SSF53681 Aspartate/glutamate racemase
111 257 InterPro IPR001920 Asp/Glu racemase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4662
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.864
5 0.411

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
C2N
6DLI
Q5SHT7 123.5 Da LogP -0.36 TPSA 63.3 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)N)Cl
DGN
1B74
P56868 146.1 Da LogP -1.34 TPSA 106.4 ✓ Ro5 ✓ Clean C(CC(=O)N)[C@H](C(=O)O)N
SIN
3IST
Q8Y7N7 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.