Protein profile

PA4666

glutamyl-tRNA reductase

Genome: NC_002516.2

Gene: PA4666 hemA Structure source: AlphaFold UniProt P42807
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Amino acids 422
Annotations 5
Features 27
PDB binders 0
Druggability 0.576

Overview

Basic information about this protein and its source genome.

Accession
PA4666
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4666 hemA
Status
annotated
Amino acids
422
Structure source
AlphaFold
EC
1.2.1.70
GO
GO:0008883 Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH. GO:0050661 Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0019353 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate. GO:0033014 The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.576
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008883 Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH.
  • GO:0050661 Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
  • GO:0019353 The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate.
  • GO:0033014 The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
4 415 NCBIfam TIGR01035 glutamyl-tRNA reductase
4 415 InterPro IPR000343 Glutamyl-tRNA reductase
170 304 Pfam PF01488 Shikimate / quinate 5-dehydrogenase
170 304 InterPro IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
315 416 SUPERFAMILY SSF69075 Glutamyl tRNA-reductase dimerization domain
315 416 InterPro IPR036453 Glutamyl tRNA-reductase dimerization domain superfamily
3 316 CDD cd05213 NAD_bind_Glutamyl_tRNA_reduct
2 159 FunFam G3DSA:3.30.460.30:FF:000001 Glutamyl-tRNA reductase
160 311 Gene3D G3DSA:3.40.50.720 -
6 154 Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain
6 154 InterPro IPR015895 Glutamyl-tRNA reductase, N-terminal
1 422 PIRSF PIRSF000445 GluTR
1 422 InterPro IPR000343 Glutamyl-tRNA reductase
160 313 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
160 313 InterPro IPR036291 NAD(P)-binding domain superfamily
2 416 Hamap MF_00087 Glutamyl-tRNA reductase [hemA].
2 416 InterPro IPR000343 Glutamyl-tRNA reductase
97 120 ProSitePatterns PS00747 Glutamyl-tRNA reductase signature.
97 120 InterPro IPR018214 Glutamyl-tRNA reductase, conserved site
159 311 FunFam G3DSA:3.40.50.720:FF:000031 Glutamyl-tRNA reductase
319 415 Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain
319 415 InterPro IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain
2 158 Gene3D G3DSA:3.30.460.30 -
2 158 InterPro IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily
1 417 PANTHER PTHR43013 GLUTAMYL-TRNA REDUCTASE
1 156 SUPERFAMILY SSF69742 Glutamyl tRNA-reductase catalytic, N-terminal domain
1 156 InterPro IPR036343 Glutamyl-tRNA reductase, N-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4666
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.576
2 0.522
9 0.319