Protein profile

PA4667

hypothetical protein

Genome: NC_002516.2

Gene: PA4667 Structure source: Experimental + AlphaFold UniProt P42810
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Amino acids 590
Annotations 1
Features 39
PDB binders 0
Druggability 0.272

Overview

Basic information about this protein and its source genome.

Accession
PA4667
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4667
Status
annotated
Amino acids
590
Structure source
Experimental + AlphaFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.516
Human E-value
5.25e-10
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.272
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

39 records
Show feature table
Start End DB Term Name
126 226 SUPERFAMILY SSF48452 TPR-like
126 226 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
508 541 ProSiteProfiles PS50005 TPR repeat profile.
508 541 InterPro IPR019734 Tetratricopeptide repeat
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
35 590 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 34 SignalP_EUK SignalP-noTM SignalP-noTM
294 366 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
294 366 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
248 305 Pfam PF14559 Tetratricopeptide repeat
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
237 293 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
237 293 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
63 548 PANTHER PTHR45586 TPR REPEAT-CONTAINING PROTEIN PA4667
240 574 SUPERFAMILY SSF48452 TPR-like
240 574 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
30 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
448 468 Coils Coil Coil
64 231 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
64 231 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
439 472 SMART SM00028 tpr_5
439 472 InterPro IPR019734 Tetratricopeptide repeat
508 541 SMART SM00028 tpr_5
235 268 SMART SM00028 tpr_5
235 268 InterPro IPR019734 Tetratricopeptide repeat
473 507 SMART SM00028 tpr_5
473 507 InterPro IPR019734 Tetratricopeptide repeat
303 336 SMART SM00028 tpr_5
303 336 InterPro IPR019734 Tetratricopeptide repeat
370 403 SMART SM00028 tpr_5
370 403 InterPro IPR019734 Tetratricopeptide repeat
405 438 SMART SM00028 tpr_5
405 438 InterPro IPR019734 Tetratricopeptide repeat
19 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
367 585 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
367 585 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
515 574 Pfam PF13432 Tetratricopeptide repeat
445 508 Pfam PF13432 Tetratricopeptide repeat
326 362 Pfam PF13432 Tetratricopeptide repeat

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7RQF
X-ray 3.50 Å A,B
89.2% 65-590
PDBe RCSB PDBj File
Viewing
AlphaFold PA4667
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.272

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.23 0.111
2 2.17 0.051
3 0.76 0.002