Protein profile

PA4674

hypothetical protein

Genome: NC_002516.2

Gene: PA4674 Structure source: Experimental + AlphaFold UniProt Q9HVC1
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Amino acids 101
Annotations 2
Features 14
PDB binders 0
Druggability 0.744

Overview

Basic information about this protein and its source genome.

Accession
PA4674
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4674
Status
annotated
Amino acids
101
Structure source
Experimental + AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.744
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLATAYAANGKQIEHEIEPLLAHG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
25 70 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
25 70 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
22 69 Pfam PF01381 Helix-turn-helix
22 69 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 99 Gene3D G3DSA:1.10.260.40 -
1 99 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
14 70 SMART SM00530 mbf_short4
14 70 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 97 PANTHER PTHR36924 ANTITOXIN HIGA-1
1 97 InterPro IPR013430 Toxin-antitoxin system, antidote protein, HigA
6 82 NCBIfam TIGR02607 HigA family addiction module antitoxin
6 82 InterPro IPR013430 Toxin-antitoxin system, antidote protein, HigA
10 91 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
10 91 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7CSV
X-ray 1.71 Å A,B
100.0% 1-101
PDBe RCSB PDBj File
Viewing
PDB 7CSW
X-ray 1.97 Å A,B
100.0% 1-101
PDBe RCSB PDBj File
Loaded
PDB 7CSY
X-ray 2.29 Å A,B,C,D
100.0% 1-101
PDBe RCSB PDBj File
Loaded
PDB 6LB3
X-ray 2.50 Å A,B,C,D,E,F,G,H
100.0% 1-101
PDBe RCSB PDBj File
Loaded
PDB 6JPI
X-ray 3.14 Å A,B,C,D
100.0% 1-101
PDBe RCSB PDBj File
Loaded
AlphaFold PA4674
AlphaFold — — full sequence — Loaded
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