Protein profile

PA4676

carbonic anhydrase

Genome: NC_002516.2

Gene: PA4676 Structure source: Experimental + AlphaFold UniProt Q9HVB9
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Amino acids 215
Annotations 4
Features 14
PDB binders 4
Druggability 0.502

Overview

Basic information about this protein and its source genome.

Accession
PA4676
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4676
Status
annotated
Amino acids
215
Structure source
Experimental + AlphaFold
EC
4.2.1.1
GO
GO:0004089 Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0008270 Binding to a zinc ion (Zn). GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.502
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0004089 Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
11 192 CDD cd00883 beta_CA_cladeA
1 202 SUPERFAMILY SSF53056 beta-carbonic anhydrase, cab
1 202 InterPro IPR036874 Carbonic anhydrase superfamily
37 187 Pfam PF00484 Carbonic anhydrase
37 187 InterPro IPR001765 Carbonic anhydrase
82 102 ProSitePatterns PS00705 Prokaryotic-type carbonic anhydrases signature 2.
82 102 InterPro IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site
1 209 Gene3D G3DSA:3.40.1050.10 Carbonic anhydrase
1 209 InterPro IPR036874 Carbonic anhydrase superfamily
3 195 PANTHER PTHR11002 CARBONIC ANHYDRASE
3 195 InterPro IPR001765 Carbonic anhydrase
30 193 SMART SM00947 Pro_CA_2
30 193 InterPro IPR001765 Carbonic anhydrase
1 211 FunFam G3DSA:3.40.1050.10:FF:000001 Carbonic anhydrase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

7 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4RXY
X-ray 1.90 Å A
100.0% 1-215
PDBe RCSB PDBj File
Viewing
PDB 5JJ8
X-ray 2.58 Å A,B
100.0% 1-215
PDBe RCSB PDBj File
Loaded
PDB 5BQ1
X-ray 1.60 Å A
96.7% 4-211
PDBe RCSB PDBj File
Loaded
PDB 6D2M
X-ray 1.90 Å A
96.7% 4-211
PDBe RCSB PDBj File
Loaded
PDB 6D2N
X-ray 1.90 Å A
96.7% 4-211
PDBe RCSB PDBj File
Loaded
PDB 6D2O
X-ray 1.90 Å A
96.7% 4-211
PDBe RCSB PDBj File
Loaded
PDB 6D2J
X-ray 2.10 Å A
96.7% 4-211
PDBe RCSB PDBj File
Loaded
AlphaFold PA4676
AlphaFold — — full sequence — Loaded
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Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

154 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

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Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
4MZ
6D2O 1.90 Å Open crystal
82.1 Da LogP 0.72 TPSA 28.7 ✓ Ro5 ✓ Clean Cc1c[nH]cn1
CO2
5BQ1 1.60 Å Open crystal
44.0 Da LogP -0.58 TPSA 34.1 ✓ Ro5 ✓ Clean C(=O)=O
FUS
6D2N 1.90 Å Open crystal
96.1 Da LogP -1.85 TPSA 86.2 ✓ Ro5 ✓ Clean NS(=O)(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.