Protein profile

PA4677

hypothetical protein

Genome: NC_002516.2

Gene: PA4677 Structure source: AlphaFold UniProt Q9HVB8
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Amino acids 412
Annotations 4
Features 6
PDB binders 0
Druggability 0.67

Overview

Basic information about this protein and its source genome.

Accession
PA4677
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4677
Status
annotated
Amino acids
412
Structure source
AlphaFold
EC
3.4.-.-
GO
GO:0070004 Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0016805 Catalysis of the hydrolysis of a dipeptide. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
58.553
Human E-value
1.74e-53
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.67
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MCDTLILRHQGQTWFAKNSDREPAEPQRLLRLPAVRNDPEARLRTTYLDIPQTAQRHALVISQPSWIWGAEMGVNEHGVAIGNEAVFTKLTRQRGTALLGMDLLRLGLERGASAREALEVITGLLQRYGQGGPAGYRDKRIRYDNSFLIADPGEAWVLETAGNLWAAKKVERWAISNALTLGHEFDLCSRDLEDQARRQGCWDGRGDFHFARVFDTRLLPWVGGAHRRCRINQRFLDSLPGEPDWHALFAALRHHGPRGDHFRRHNNRQVCMHAGSFWRPSQTTASLVARLRDDGPLLAATGTSAPCLGLFQPLSFDPASGAAVLSQPREAVQESPWWRFEAVHRRALTDRAFRRLLRSGRDWLERELFADLEQPDWPRLAEDAAAWHACWHDQVAMQPLAQQRWWRSHAAL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0070004 Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
  • GO:0016805 Catalysis of the hydrolysis of a dipeptide.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
2 395 PANTHER PTHR12994 SECERNIN
2 395 InterPro IPR005322 Peptidase C69
11 214 Pfam PF03577 Peptidase family C69
11 214 InterPro IPR005322 Peptidase C69
2 309 Gene3D G3DSA:3.60.60.10 Penicillin V Acylase; Chain A
2 309 FunFam G3DSA:3.60.60.10:FF:000012 Dipeptidase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4677
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.67