Protein profile

PA4688

iron (III)-transporter permease HitB

Genome: NC_002516.2

Gene: hitB PA4688 Structure source: AlphaFold UniProt Q9HVA7
Export view
Amino acids 512
Annotations 3
Features 62
PDB binders 0
Druggability 0.796

Overview

Basic information about this protein and its source genome.

Accession
PA4688
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
hitB PA4688
Status
annotated
Amino acids
512
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.796
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

62 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
313 504 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
313 504 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
482 503 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
38 60 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
504 512 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 166 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
122 146 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
333 496 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
333 496 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
75 240 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
75 240 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
275 297 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
82 92 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
341 351 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
385 406 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
167 189 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
455 475 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 81 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
320 495 CDD cd06261 TM_PBP2
320 495 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
58 239 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
58 239 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
374 384 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
427 449 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 32 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
407 426 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
194 220 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
476 481 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
270 503 SUPERFAMILY SSF161098 MetI-like
270 503 InterPro IPR035906 MetI-like superfamily
450 454 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
352 373 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 146 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 121 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
298 316 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
427 449 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
317 340 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
482 504 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
317 339 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 226 CDD cd06261 TM_PBP2
58 226 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
8 250 SUPERFAMILY SSF161098 MetI-like
8 250 InterPro IPR035906 MetI-like superfamily
33 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
384 406 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
241 274 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
352 374 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
221 240 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 297 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
221 240 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
61 83 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
299 508 Gene3D G3DSA:1.10.3720.10 -
299 508 InterPro IPR035906 MetI-like superfamily
12 245 Gene3D G3DSA:1.10.3720.10 -
12 245 InterPro IPR035906 MetI-like superfamily
7 511 PANTHER PTHR43357 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
167 193 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4688
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.796
14 0.59
5 0.383
19 0.326