Protein profile

PA4689

hypothetical protein

Genome: NC_002516.2

Gene: PA4689 Structure source: AlphaFold UniProt Q9HVA6
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Amino acids 768
Annotations 2
Features 17
PDB binders 0
Druggability 0.753

Overview

Basic information about this protein and its source genome.

Accession
PA4689
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4689
Status
annotated
Amino acids
768
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0061024 A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.753
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSDLPSPKKHKTSNWSAIWVLPLVALAIGAWLAWRAFDQAGVDIQVRFESGDGIQANKTEVLYKGISVGKVTDLHVSKDIKGVVATIEIKKEAQEYLSKDTRFWLVKPRVSLAGVTGLETLVSGVYIAVDPVKGEKEERYFTALKEPPPLSDKLPGLHLTLKADRLGSLEQGSPVFYRQIQVGQVKSFQLGDDQRTIEIKVHIEPAYADLVRKHTRFWNASGISISGGLSGFKVHSESLLTLVAGGIAFSTPENRTDSPPTDPSKPFRLYDDYDAAQAGLRVKLKMNDVSGIDPGRTPVMFNGVQVGLVKSIDMGKDYSSATADLAMDPRVEDMLLEGTEFWTVKPSISLAGITGLEALVKGNYIDVRFAKSGAPSREFTIRPKAPPLNTDAPGLHLVLTSDKLGSIDIGAPILYRQVRVGSVQSYQLSRDRQRVVVGVHIEPEYAHLVNTSTRFWNSSGITLTGNLSGVQVKSESLQTLITGGISFDTLDPKAPTVTKVRRFTLFDSEEAAMARGVEIQLSIDNADGLREGTPIRFKGLDIGKIESVELNPDLSGVLMKARLTSAGERVARSGTRFWVVRPALGLLRTENLGTLVSGPYIEALPSSTPGERQARFQTLAEAPNLLGRENGLRLTLSAPRKGSIKPGNLVTYRQIPVGKVVDLALGEQADRVLISILIEPRYVPLVRTGSRFWNASGFGVDASLFKGLSLRTESMEALMEGGIAFATPNNAQMGEPAKPGQTFALFDSANDEWLEWAPKIPLKETARR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0061024 A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
395 463 Pfam PF02470 MlaD protein
395 463 InterPro IPR003399 Mce/MlaD
156 216 Pfam PF02470 MlaD protein
156 216 InterPro IPR003399 Mce/MlaD
280 369 Pfam PF02470 MlaD protein
280 369 InterPro IPR003399 Mce/MlaD
41 131 Pfam PF02470 MlaD protein
41 131 InterPro IPR003399 Mce/MlaD
516 602 Pfam PF02470 MlaD protein
516 602 InterPro IPR003399 Mce/MlaD
631 691 Pfam PF02470 MlaD protein
631 691 InterPro IPR003399 Mce/MlaD
1 331 PANTHER PTHR30462 UNCHARACTERIZED
35 768 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4689
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.753