Protein profile

PA4708

heme-transporter PhuT

Genome: NC_002516.2

Gene: phuT PA4708 Structure source: AlphaFold UniProt Q9HV90

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Amino acids 297

Annotations 0

Features 16

PDB binders 0

Druggability 0.961

Overview

Basic information about this protein and its source genome.

Accession: PA4708
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: phuT PA4708
Status: annotated
Amino acids: 297
Structure source: AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.961

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
31	262	Pfam	PF01497	Periplasmic binding protein
31	262	InterPro	IPR002491	ABC transporter periplasmic binding domain
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	23	SignalP_EUK	SignalP-noTM	SignalP-noTM
27	286	SUPERFAMILY	SSF53807	Helical backbone metal receptor
27	264	CDD	cd01149	HutB
29	288	ProSiteProfiles	PS50983	Iron siderophore/cobalamin periplasmic-binding domain profile.
29	288	InterPro	IPR002491	ABC transporter periplasmic binding domain
6	16	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
18	143	Gene3D	G3DSA:3.40.50.1980	Nitrogenase molybdenum iron protein domain
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
17	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
148	297	Gene3D	G3DSA:3.40.50.1980	Nitrogenase molybdenum iron protein domain
24	297	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26	289	PANTHER	PTHR30535	VITAMIN B12-BINDING PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4708	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.738
1				0.455