Protein profile

PA4709

hemin degrading factor

Genome: NC_002516.2

Gene: PA4709 Structure source: AlphaFold UniProt Q9HV89

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Amino acids 354

Annotations 2

Features 9

PDB binders 0

Druggability 0.518

Overview

Basic information about this protein and its source genome.

Accession: PA4709
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4709
Status: annotated
Amino acids: 354
Structure source: AlphaFold

GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.518

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0006826 The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
197	350	CDD	cd16831	HemS-like_C
91	346	Gene3D	G3DSA:3.40.1570.10	HemS/ChuS/ChuX like domains
14	167	CDD	cd16830	HemS-like_N
220	351	Pfam	PF05171	Haemin-degrading HemS.ChuX domain
220	351	InterPro	IPR007845	Haemin-degrading HemS/ChuX domain
38	167	Pfam	PF05171	Haemin-degrading HemS.ChuX domain
38	167	InterPro	IPR007845	Haemin-degrading HemS/ChuX domain
14	351	SUPERFAMILY	SSF144064	Heme iron utilization protein-like
18	294	Gene3D	G3DSA:3.40.1570.10	HemS/ChuS/ChuX like domains

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4709	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.518
2				0.368