Protein profile

PA4721

sugar fermentation stimulation protein A

Genome: NC_002516.2

Gene: sfsA PA4721 Structure source: AlphaFold UniProt Q9HV77
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Amino acids 235
Annotations 1
Features 16
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
PA4721
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
sfsA PA4721
Status
annotated
Amino acids
235
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 80 Gene3D G3DSA:2.40.50.580 -
81 235 Gene3D G3DSA:3.40.1350.60 -
5 233 NCBIfam TIGR00230 DNA/RNA nuclease SfsA
5 233 InterPro IPR005224 Sugar fermentation stimulation protein
4 234 PANTHER PTHR30545 SUGAR FERMENTATION STIMULATION PROTEIN A
4 234 InterPro IPR005224 Sugar fermentation stimulation protein
11 234 CDD cd22359 SfsA-like_bacterial
11 234 InterPro IPR005224 Sugar fermentation stimulation protein
13 79 Pfam PF17746 SfsA N-terminal OB domain
13 79 InterPro IPR041465 SfsA, N-terminal OB domain
1 80 FunFam G3DSA:2.40.50.580:FF:000001 Sugar fermentation stimulation protein A
81 235 FunFam G3DSA:3.40.1350.60:FF:000001 Sugar fermentation stimulation protein A
1 235 Hamap MF_00095 Sugar fermentation stimulation protein A [sfsA].
1 235 InterPro IPR005224 Sugar fermentation stimulation protein
84 223 Pfam PF03749 Sugar fermentation stimulation protein RE domain
84 223 InterPro IPR040452 Sugar fermentation stimulation protein, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4721
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.294