Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4743
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4743 rbfA
Status: annotated
Amino acids: 129
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043024 Binding to a small ribosomal subunit. GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. GO:0042254 A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.32

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0043024 Binding to a small ribosomal subunit.
GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
GO:0042254 A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
3	127	PANTHER	PTHR33515	RIBOSOME-BINDING FACTOR A, CHLOROPLASTIC-RELATED
3	127	InterPro	IPR000238	Ribosome-binding factor A
6	112	Hamap	MF_00003	Ribosome-binding factor A [rbfA].
6	112	InterPro	IPR000238	Ribosome-binding factor A
1	114	NCBIfam	TIGR00082	30S ribosome-binding factor RbfA
1	114	InterPro	IPR000238	Ribosome-binding factor A
78	99	ProSitePatterns	PS01319	Ribosome-binding factor A signature.
78	99	InterPro	IPR020053	Ribosome-binding factor A, conserved site
2	106	SUPERFAMILY	SSF89919	Ribosome-binding factor A, RbfA
2	106	InterPro	IPR023799	Ribosome-binding factor A domain superfamily
4	119	Gene3D	G3DSA:3.30.300.20	-
4	119	InterPro	IPR015946	K homology domain-like, alpha/beta
4	119	FunFam	G3DSA:3.30.300.20:FF:000029	Ribosome-binding factor A
7	112	Pfam	PF02033	Ribosome-binding factor A
7	112	InterPro	IPR000238	Ribosome-binding factor A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4743	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.32

PA4743