Protein profile

PA4752

cell division protein FtsJ

Genome: NC_002516.2

Gene: rlmE rrmJ PA4752 ftsJ Structure source: AlphaFold UniProt P95454

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Amino acids 207

Annotations 6

Features 13

PDB binders 0

Druggability 0.652

Overview

Basic information about this protein and its source genome.

Accession: PA4752
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: rlmE rrmJ PA4752 ftsJ
Status: annotated
Amino acids: 207
Structure source: AlphaFold

2.1.1.166

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008650 Catalysis of the reaction: a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H+. GO:0001510 Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 47.222
Human E-value: 7.98e-20
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.652

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

2.1.1.166

Gene Ontology (GO)

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0008650 Catalysis of the reaction: a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H+.
GO:0001510 Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
25	206	FunFam	G3DSA:3.40.50.150:FF:000005	Ribosomal RNA large subunit methyltransferase E
27	205	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases
27	205	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
51	163	CDD	cd02440	AdoMet_MTases
25	207	Gene3D	G3DSA:3.40.50.150	Vaccinia Virus protein VP39
25	207	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
12	205	Hamap	MF_01547	Ribosomal RNA large subunit methyltransferase E [rlmE].
12	205	InterPro	IPR015507	Ribosomal RNA large subunit methyltransferase E
10	205	PANTHER	PTHR10920	RIBOSOMAL RNA METHYLTRANSFERASE
1	207	PIRSF	PIRSF005461	23S_rRNA_mtase
1	207	InterPro	IPR015507	Ribosomal RNA large subunit methyltransferase E
28	204	Pfam	PF01728	FtsJ-like methyltransferase
28	204	InterPro	IPR002877	Ribosomal RNA methyltransferase, FtsJ domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4752	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.652