Protein profile

PA4753

hypothetical protein

Genome: NC_002516.2

Gene: PA4753 Structure source: AlphaFold UniProt P95453
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Amino acids 104
Annotations 6
Features 13
PDB binders 0
Druggability 0.624

Overview

Basic information about this protein and its source genome.

Accession
PA4753
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4753
Status
annotated
Amino acids
104
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990275 Binding to a preribosome. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0000027 The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0000028 The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. GO:0000967 Any process involved in forming the mature 5' end of an rRNA molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.624
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:1990275 Binding to a preribosome.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0000027 The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
  • GO:0000028 The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
  • GO:0000967 Any process involved in forming the mature 5' end of an rRNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
3 86 Pfam PF01985 CRS1 / YhbY (CRM) domain
3 86 InterPro IPR001890 RNA-binding, CRM domain
37 57 Coils Coil Coil
3 86 SMART SM01103 CRS1_YhbY_2
1 96 SUPERFAMILY SSF75471 YhbY-like
1 96 InterPro IPR035920 YhbY-like superfamily
1 100 Gene3D G3DSA:3.30.110.60 -
1 100 InterPro IPR035920 YhbY-like superfamily
1 97 ProSiteProfiles PS51295 CRM domain profile.
1 97 InterPro IPR001890 RNA-binding, CRM domain
3 94 NCBIfam TIGR00253 ribosome assembly RNA-binding protein YhbY
3 94 InterPro IPR017924 RNA-binding protein YhbY
1 96 PANTHER PTHR40065 RNA-BINDING PROTEIN YHBY

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4753
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.624