Protein profile

PA4755

transcription elongation factor GreA

Genome: NC_002516.2

Gene: PA4755 greA Structure source: AlphaFold UniProt Q9HV46
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Amino acids 158
Annotations 4
Features 25
PDB binders 0
Druggability 0.393

Overview

Basic information about this protein and its source genome.

Accession
PA4755
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4755 greA
Status
annotated
Amino acids
158
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0070063 Binding to an RNA polymerase molecule or complex. GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.393
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0070063 Binding to an RNA polymerase molecule or complex.
  • GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
  • GO:0032784 Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
82 157 SUPERFAMILY SSF54534 FKBP-like
17 48 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1.
17 48 InterPro IPR018151 Transcription elongation factor, GreA/GreB, conserved site
76 158 Gene3D G3DSA:3.10.50.30 -
76 158 InterPro IPR036953 Transcription elongation factor GreA/GreB, C-terminal domain superfamily
1 76 FunFam G3DSA:1.10.287.180:FF:000001 Transcription elongation factor GreA
5 74 Pfam PF03449 Transcription elongation factor, N-terminal
5 74 InterPro IPR022691 Transcription elongation factor, GreA/GreB, N-terminal
3 78 SUPERFAMILY SSF46557 GreA transcript cleavage protein, N-terminal domain
3 78 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
1 158 PIRSF PIRSF006092 GreA_GreB
1 158 InterPro IPR023459 Transcription elongation factor GreA/GreB family
1 75 Gene3D G3DSA:1.10.287.180 -
1 75 InterPro IPR036805 Transcription elongation factor, GreA/GreB, N-terminal domain superfamily
121 137 ProSitePatterns PS00830 Prokaryotic transcription elongation factors signature 2.
121 137 InterPro IPR018151 Transcription elongation factor, GreA/GreB, conserved site
5 155 NCBIfam TIGR01462 transcription elongation factor GreA
5 155 InterPro IPR006359 Transcription elongation factor GreA
83 156 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term
83 156 InterPro IPR001437 Transcription elongation factor, GreA/GreB, C-terminal
2 156 Hamap MF_00105 Transcription elongation factor GreA [greA].
2 156 InterPro IPR028624 Transcription elongation factor GreA/GreB
81 158 FunFam G3DSA:3.10.50.30:FF:000001 Transcription elongation factor GreA
3 157 PANTHER PTHR30437 TRANSCRIPTION ELONGATION FACTOR GREA
3 157 InterPro IPR023459 Transcription elongation factor GreA/GreB family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4755
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.393
3 0.217