Protein profile

PA4767

hypothetical protein

Genome: NC_002516.2

Gene: ratA PA4767 Structure source: AlphaFold UniProt O68560

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Amino acids 144

Annotations 3

Features 10

PDB binders 0

Druggability 0.963

Overview

Basic information about this protein and its source genome.

Accession: PA4767
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ratA PA4767
Status: annotated
Amino acids: 144
Structure source: AlphaFold

GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units. GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 25.18
Human E-value: 1.27e-12
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.963

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units.
GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
5	142	CDD	cd07813	COQ10p_like
5	142	InterPro	IPR044996	Coenzyme Q-binding protein COQ10-like
3	144	FunFam	G3DSA:3.30.530.20:FF:000061	Ribosome association toxin RatA
11	135	Pfam	PF03364	Polyketide cyclase / dehydrase and lipid transport
11	135	InterPro	IPR005031	Coenzyme Q-binding protein COQ10, START domain
1	144	SUPERFAMILY	SSF55961	Bet v1-like
3	144	Gene3D	G3DSA:3.30.530.20	-
3	144	InterPro	IPR023393	START-like domain superfamily
4	144	PANTHER	PTHR12901	SPERM PROTEIN HOMOLOG
4	144	InterPro	IPR044996	Coenzyme Q-binding protein COQ10-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4767	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.963