Protein profile

PA4768

SsrA-binding protein

Genome: NC_002516.2

Gene: smpB PA4768 Structure source: AlphaFold UniProt Q9HV40
Export view
Amino acids 159
Annotations 3
Features 16
PDB binders 0
Druggability 0.739

Overview

Basic information about this protein and its source genome.

Accession
PA4768
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
smpB PA4768
Status
annotated
Amino acids
159
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0070929 A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.739
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MAKQKKHPSGTIAQNKKALHDYFIEQRFEAGVALAGWEVKSLRAGKAQLVDSYVLLKDGEAWLLGSHITPLTTASTHVIADPVRTRKLLLHKRELGKLFGAVQQKGYACVALSMYWKKHLVKCEIALAKGKKDFDKRHTEKERDSDREIQRAMRHGKDD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0070929 A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
12 154 Pfam PF01668 SmpB protein
12 154 InterPro IPR000037 SsrA-binding protein
1 159 Hamap MF_00023 SsrA-binding protein [smpB].
1 159 InterPro IPR000037 SsrA-binding protein
4 133 Gene3D G3DSA:2.40.280.10 -
4 133 InterPro IPR023620 Small protein B
136 159 MobiDBLite mobidb-lite consensus disorder prediction
12 154 NCBIfam TIGR00086 SsrA-binding protein
5 136 SUPERFAMILY SSF74982 Small protein B (SmpB)
5 136 InterPro IPR023620 Small protein B
15 131 CDD cd09294 SmpB
15 131 InterPro IPR000037 SsrA-binding protein
30 42 ProSitePatterns PS01317 SsrA-binding protein.
30 42 InterPro IPR020081 SsrA-binding protein, conserved site
1 155 PANTHER PTHR30308 TMRNA-BINDING COMPONENT OF TRANS-TRANSLATION TAGGING COMPLEX
1 155 InterPro IPR000037 SsrA-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4768
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.739
5 0.36
1 0.324