Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4788
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4788
Status: annotated
Amino acids: 285
Structure source: AlphaFold

GO

GO:0005835 A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. GO:0004312 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.867

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005835 A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
GO:0004312 Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
1	281	PANTHER	PTHR43841	3-HYDROXYACYL-THIOESTER DEHYDRATASE HTDX-RELATED
180	254	Pfam	PF01575	MaoC like domain
180	254	InterPro	IPR002539	MaoC-like dehydratase domain
34	281	Gene3D	G3DSA:3.10.129.10	Hotdog Thioesterase
43	153	SUPERFAMILY	SSF54637	Thioesterase/thiol ester dehydrase-isomerase
43	153	InterPro	IPR029069	HotDog domain superfamily
181	203	PRINTS	PR01483	Fatty acid synthase signature
181	203	InterPro	IPR003965	Fatty acid synthase
203	224	PRINTS	PR01483	Fatty acid synthase signature
203	224	InterPro	IPR003965	Fatty acid synthase
174	260	SUPERFAMILY	SSF54637	Thioesterase/thiol ester dehydrase-isomerase
174	260	InterPro	IPR029069	HotDog domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4788	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.867

PA4788