Protein profile

PA4809

formate dehydrogenase subunit epsilon

Genome: NC_002516.2

Gene: fdhE PA4809 Structure source: Experimental + AlphaFold UniProt Q9HV00
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Amino acids 309
Annotations 4
Features 17
PDB binders 0
Druggability 0.603

Overview

Basic information about this protein and its source genome.

Accession
PA4809
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fdhE PA4809
Status
annotated
Amino acids
309
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008199 Binding to a ferric iron ion, Fe(III). GO:0051604 Any process leading to the attainment of the full functional capacity of a protein. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.603
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008199 Binding to a ferric iron ion, Fe(III).
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
19 309 Gene3D G3DSA:3.90.1670.10 -
19 309 InterPro IPR024064 FdhE-like superfamily
3 307 Hamap MF_00611 Protein FdhE [fdhE].
3 307 InterPro IPR006452 Formate dehydrogenase accessory protein
20 307 SUPERFAMILY SSF144020 FdhE-like
20 307 InterPro IPR024064 FdhE-like superfamily
1 308 PANTHER PTHR37689 PROTEIN FDHE
1 308 InterPro IPR006452 Formate dehydrogenase accessory protein
19 309 FunFam G3DSA:3.90.1670.10:FF:000001 Protein FdhE
46 294 CDD cd16341 FdhE
46 294 InterPro IPR006452 Formate dehydrogenase accessory protein
2 306 NCBIfam TIGR01562 formate dehydrogenase accessory protein FdhE
2 306 InterPro IPR006452 Formate dehydrogenase accessory protein
1 309 PIRSF PIRSF018296 Format_dh_formtn_FdhE
1 309 InterPro IPR006452 Formate dehydrogenase accessory protein
16 304 Pfam PF04216 Protein involved in formate dehydrogenase formation
16 304 InterPro IPR006452 Formate dehydrogenase accessory protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2FIY
X-ray 2.10 Å A,B
100.0% 1-309
PDBe RCSB PDBj File
Viewing
AlphaFold PA4809
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.603
1 0.231

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.68 0.274
2 4.53 0.194
3 3.22 0.111
4 1.78 0.033