Protein profile

PA4836

hypothetical protein

Genome: NC_002516.2

Gene: zrmB PA4836 cntL Structure source: AlphaFold UniProt Q9HUX4
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Amino acids 263
Annotations 3
Features 8
PDB binders 0
Druggability 0.941

Overview

Basic information about this protein and its source genome.

Accession
PA4836
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
zrmB PA4836 cntL
Status
annotated
Amino acids
263
Structure source
AlphaFold
EC
2.5.1.-
GO
GO:0030410 Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine. GO:0030418 The chemical reactions and pathways resulting in the formation of nicotianamine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.941
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0030410 Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine.
  • GO:0030418 The chemical reactions and pathways resulting in the formation of nicotianamine.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
118 246 Pfam PF03059 Nicotianamine synthase protein
118 246 InterPro IPR004298 Nicotianamine synthase
111 220 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
111 220 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
102 247 PANTHER PTHR32266 NICOTIANAMINE SYNTHASE 3
102 247 InterPro IPR004298 Nicotianamine synthase
32 259 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
32 259 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4836
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.941
2 0.508