Amino acids
123
Annotations
5
Features
19
PDB binders
0
Overview
Basic information about this protein and its source genome.
- Accession
- PA4840
- Gene
- PA4840
- Status
- annotated
- Amino acids
- 123
- Structure source
- AlphaFold
GO
GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
GO:0001731 The joining of the small ribosomal subunit, ternary complex, and mRNA.
GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
GO:0002188 A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Unknown
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
5 GO
Gene Ontology (GO)
5- GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
- GO:0001731 The joining of the small ribosomal subunit, ternary complex, and mRNA.
- GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
- GO:0002188 A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
- GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Sequence Features
Domain/signature hits from InterPro and related databases.
19 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 49 | 116 | Pfam | PF01253 | Translation initiation factor SUI1 |
| 49 | 116 | InterPro | IPR001950 | SUI1 domain |
| 1 | 17 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 49 | 113 | PANTHER | PTHR12789 | DENSITY-REGULATED PROTEIN HOMOLOG |
| 13 | 17 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 1 | 123 | PIRSF | PIRSF037511 | Transl_init_SUI1_prok |
| 1 | 123 | InterPro | IPR005872 | Archaeal/bacterial translation initiation factor SUI1 |
| 52 | 115 | ProSiteProfiles | PS50296 | Translation initiation factor SUI1 family profile. |
| 52 | 115 | InterPro | IPR001950 | SUI1 domain |
| 5 | 12 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 14 | 123 | NCBIfam | TIGR01158 | stress response translation initiation inhibitor YciH |
| 14 | 123 | InterPro | IPR005872 | Archaeal/bacterial translation initiation factor SUI1 |
| 46 | 121 | CDD | cd11567 | YciH_like |
| 46 | 121 | InterPro | IPR005872 | Archaeal/bacterial translation initiation factor SUI1 |
| 18 | 123 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 4 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 43 | 123 | Gene3D | G3DSA:3.30.780.10 | - |
| 13 | 120 | SUPERFAMILY | SSF55159 | eIF1-like |
| 13 | 120 | InterPro | IPR036877 | SUI1 domain superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed AlphaFold model PA4840 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA4840
|
AlphaFold | — | — | full sequence | — | Viewing |