Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4844
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ctpL PA4844
Status: annotated
Amino acids: 657
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0010247 The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.881

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0010247 The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal.
GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
6	27	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
385	621	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
385	621	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
28	303	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7	29	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
304	322	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
358	657	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
327	657	Gene3D	G3DSA:1.10.287.950	-
323	657	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
469	622	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
469	622	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
463	483	Coils	Coil	Coil
1	5	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
395	656	SMART	SM00283	MA_2
395	656	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
327	657	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
183	203	Coils	Coil	Coil
423	620	CDD	cd11386	MCP_signal
71	656	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
423	452	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
423	452	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
522	551	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
522	551	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
536	578	Coils	Coil	Coil
327	380	ProSiteProfiles	PS50885	HAMP domain profile.
327	380	InterPro	IPR003660	HAMP domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4844	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.881
6				0.338
8				0.258
3				0.214

PA4844