Protein profile

PA4850

50S ribosomal protein L11 methyltransferase

Genome: NC_002516.2

Gene: prmA PA4850 Structure source: AlphaFold UniProt Q9HUW3
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Amino acids 294
Annotations 6
Features 13
PDB binders 3
Druggability 0.684

Overview

Basic information about this protein and its source genome.

Accession
PA4850
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
prmA PA4850
Status
annotated
Amino acids
294
Structure source
AlphaFold
EC
2.1.1.-
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016279 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0006479 The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.25
Human E-value
1.11e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.684
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPWLQVRLAITPEQAETYEDALLEVGAVSVTFMDAEDQPIFEPDLGTTPLWSRTHLLALFEADTDETALLAHLALLTGGDLPEHHVEEIADQDWERSWMDNFQPMRFGRRLWIVPSWHAAPEPDAVNLLLDPGLAFGTGTHPTTALCLEWLDGQELAGRQVLDFGCGSGILAIAALLLGAERAVGTDIDPQALEASRDNASRNGIEPARFPVYLPADLPQRQADVLVANILAGPLVSLAPQLTGLVRPGGLLALSGILAEQAEEVRAAYSAHFDLDPTAEREGWIRISGRRRAD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016279 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
  • GO:0006479 The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
3 285 NCBIfam TIGR00406 50S ribosomal protein L11 methyltransferase
3 285 InterPro IPR004498 Ribosomal protein L11 methyltransferase
1 293 PIRSF PIRSF000401 RPL11_MTase
1 293 InterPro IPR004498 Ribosomal protein L11 methyltransferase
3 291 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA)
1 292 PANTHER PTHR43648 ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE
63 280 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
63 280 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
1 291 Hamap MF_00735 Ribosomal protein L11 methyltransferase [prmA].
1 291 InterPro IPR004498 Ribosomal protein L11 methyltransferase
161 259 CDD cd02440 AdoMet_MTases
100 294 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
100 294 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4850
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.684
4 0.634
2 0.276
6 0.208

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2MM
3CJQ
Q84BQ9 177.3 Da LogP 0.75 TPSA 40.5 ✓ Ro5 ✓ Clean CN(C)[C@@H](CCSC)C(=O)O
PG0
6H2V
Q9NRN9 120.1 Da LogP -0.36 TPSA 38.7 ✓ Ro5 ✓ Clean COCCOCCO
SFG
2ZBR
Q84BQ9 381.4 Da LogP -2.06 TPSA 208.7 2 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.