Protein profile

PA4853

Fis family transcriptional regulator

Genome: NC_002516.2

Gene: fis Structure source: ColabFold
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Amino acids 107
Annotations 3
Features 20
PDB binders 0
Druggability 0.961

Overview

Basic information about this protein and its source genome.

Accession
PA4853
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fis
Status
annotated
Amino acids
107
Structure source
ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.961
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
13 106 PANTHER PTHR47918 DNA-BINDING PROTEIN FIS
87 107 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
87 107 InterPro IPR002197 DNA binding HTH domain, Fis-type
70 87 PRINTS PR01590 FIS bacterial regulatory protein HTH signature
70 87 InterPro IPR002197 DNA binding HTH domain, Fis-type
9 107 PIRSF PIRSF002097 DNA-bp_Fis
9 107 InterPro IPR005412 DNA-binding protein Fis
1 37 MobiDBLite mobidb-lite consensus disorder prediction
66 104 Pfam PF02954 Bacterial regulatory protein, Fis family
66 104 InterPro IPR002197 DNA binding HTH domain, Fis-type
66 78 PRINTS PR01591 DNA-binding protein FIS signature
66 78 InterPro IPR005412 DNA-binding protein Fis
35 51 PRINTS PR01591 DNA-binding protein FIS signature
35 51 InterPro IPR005412 DNA-binding protein Fis
51 66 PRINTS PR01591 DNA-binding protein FIS signature
51 66 InterPro IPR005412 DNA-binding protein Fis
24 106 SUPERFAMILY SSF46689 Homeodomain-like
24 106 InterPro IPR009057 Homeobox-like domain superfamily
13 106 Gene3D G3DSA:1.10.10.60 -
13 107 FunFam G3DSA:1.10.10.60:FF:000006 DNA-binding protein Fis

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA4853
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.961
2 0.88