Protein profile
PA4859
ABC transporter permease
Genome: NC_002516.2
Amino acids
529
Annotations
3
Features
38
PDB binders
0
Druggability
0.949
Overview
Basic information about this protein and its source genome.
- Accession
- PA4859
- Gene
- NP_253546.2
- Status
- annotated
- Amino acids
- 529
- Structure source
- ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- CytoplasmicMembrane
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.949
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
3 GO
Gene Ontology (GO)
3- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
- GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
Sequence Features
Domain/signature hits from InterPro and related databases.
38 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 494 | 513 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 329 | 351 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 233 | 527 | PANTHER | PTHR11795 | BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE PROTEIN LIVH |
| 243 | 264 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 491 | 513 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 514 | 529 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 464 | 486 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 237 | 512 | Pfam | PF02653 | Branched-chain amino acid transport system / permease component |
| 237 | 512 | InterPro | IPR001851 | ABC transporter, permease |
| 328 | 350 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 375 | 397 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 11 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 242 | 264 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 235 | 526 | NCBIfam | TIGR03409 | urea ABC transporter permease subunit UrtB |
| 235 | 526 | InterPro | IPR017779 | ABC transporter, urea permease protein UrtB, bacterial-type |
| 1 | 27 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 271 | 290 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 317 | 327 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 1 | 27 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 271 | 290 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 256 | 521 | CDD | cd06582 | TM_PBP1_LivH_like |
| 464 | 488 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 27 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM |
| 291 | 295 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 351 | 379 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 24 | 27 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 380 | 397 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 125 | 225 | SUPERFAMILY | SSF48371 | ARM repeat |
| 125 | 225 | InterPro | IPR016024 | Armadillo-type fold |
| 265 | 270 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 28 | 242 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 294 | 316 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 489 | 493 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 112 | 252 | Gene3D | G3DSA:1.25.10.10 | - |
| 112 | 252 | InterPro | IPR011989 | Armadillo-like helical |
| 12 | 23 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 296 | 316 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 398 | 463 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
ColabFold
PA4859
|
ColabFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 9 | 0.917 | ||||||
| 6 | 0.792 | ||||||
| 1 | 0.538 | ||||||
| 10 | 0.448 |