Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4863
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4863
Status: annotated
Amino acids: 150
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1905502 Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component. GO:0004596 Catalysis of the reaction: acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-alpha-aminoacyl-[protein]. GO:0008064 Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.559

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:1905502 Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component.
GO:0004596 Catalysis of the reaction: acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-alpha-aminoacyl-[protein].
GO:0008064 Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
1	12	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3	150	ProSiteProfiles	PS51186	Gcn5-related N-acetyltransferase (GNAT) domain profile.
3	150	InterPro	IPR000182	GNAT domain
13	32	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
33	150	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
3	144	PANTHER	PTHR13538	N-ACETYLTRANSFERASE 6
3	144	InterPro	IPR039840	N-alpha-acetyltransferase 80
35	129	Pfam	PF00583	Acetyltransferase (GNAT) family
35	129	InterPro	IPR000182	GNAT domain
1	150	Gene3D	G3DSA:3.40.630.30	-
1	149	SUPERFAMILY	SSF55729	Acyl-CoA N-acyltransferases (Nat)
1	149	InterPro	IPR016181	Acyl-CoA N-acyltransferase
13	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
51	112	CDD	cd04301	NAT_SF
1	150	FunFam	G3DSA:3.40.630.30:FF:000206	GNAT family N-acetyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4863	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.559
1				0.324

PA4863