Protein profile

PA4864

urease accessory protein

Genome: NC_002516.2

Gene: ureD PA4864 Structure source: AlphaFold UniProt Q9HUU9
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Amino acids 280
Annotations 5
Features 6
PDB binders 0
Druggability 0.897

Overview

Basic information about this protein and its source genome.

Accession
PA4864
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ureD PA4864
Status
annotated
Amino acids
280
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016151 Binding to a nickel (Ni) cation. GO:0018237 Increases the activity of urease by promoting the incorporation of nickel into the active site. GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0018237 Increases the activity of urease by promoting the incorporation of nickel into the active site.
  • GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
57 253 Pfam PF01774 UreD urease accessory protein
57 253 InterPro IPR002669 Urease accessory protein UreD
14 264 Hamap MF_01384 Urease accessory protein UreD [ureD].
14 264 InterPro IPR002669 Urease accessory protein UreD
13 265 PANTHER PTHR33643 UREASE ACCESSORY PROTEIN D
13 265 InterPro IPR002669 Urease accessory protein UreD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4864
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.897
2 0.242