Protein profile

PA4867

urease subunit beta

Genome: NC_002516.2

Gene: PA4867 ureB Structure source: AlphaFold UniProt Q9HUU6
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Amino acids 101
Annotations 4
Features 12
PDB binders 0
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
PA4867
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4867 ureB
Status
annotated
Amino acids
101
Structure source
AlphaFold
EC
3.5.1.5
GO
GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
  • GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.
  • GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 101 SUPERFAMILY SSF51278 Urease, beta-subunit
1 101 InterPro IPR036461 Urease, beta subunit superfamily
1 100 PANTHER PTHR33569 UREASE
1 101 Gene3D G3DSA:2.10.150.10 Urease, beta subunit
1 101 CDD cd00407 Urease_beta
1 101 InterPro IPR002019 Urease, beta subunit-like
3 99 Pfam PF00699 Urease beta subunit
3 99 InterPro IPR002019 Urease, beta subunit-like
1 101 Hamap MF_01954 Urease subunit beta [ureB].
1 101 FunFam G3DSA:2.10.150.10:FF:000001 Urease subunit beta
1 99 NCBIfam TIGR00192 urease subunit beta
1 99 InterPro IPR002019 Urease, beta subunit-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4867
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.906