Protein target profile

PA4870

hypothetical protein

Genome: NC_002516.2

Gene: PA4870 3D evidence: AlphaFold DB model UniProt Q9HUU3

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Length 88

Pocket druggability 0.71

EC / GO 0 / 2

Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

4 signals

Strengths

Risks / watch

No major risk signal surfaced in the loaded evidence.

Missing evidence

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.

How to read this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Overview

Basic information about this protein and its source genome.

Accession: PA4870
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4870
Status: annotated
Amino acids: 88
3D evidence: AlphaFold DB model

GO:0008270 Binding to a zinc ion (Zn). GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: Hit
Essential (DEG): Y
Localization: Unknown

Selected pocket evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.71

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MASGWANDGAVQEQIDSTIEDAIARARSQLPRGESLTHCEECDATIPEARRRAIPGVRLCVNCQTEHDREQAKFSGYNRRGSKDSQLR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0008270 Binding to a zinc ion (Zn).
GO:1900378 Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
37	69	Pfam	PF01258	Prokaryotic dksA/traR C4-type zinc finger
37	69	InterPro	IPR000962	Zinc finger, DksA/TraR C4-type
6	73	FunFam	G3DSA:1.20.120.910:FF:000002	DksA/TraR family C4-type zinc finger protein
38	73	SUPERFAMILY	SSF57716	Glucocorticoid receptor-like (DNA-binding domain)
39	50	PRINTS	PR00618	DksA/TraR zinc finger signature
39	50	InterPro	IPR020460	Zinc finger, DksA/TraR C4-type, bacteria
51	63	PRINTS	PR00618	DksA/TraR zinc finger signature
51	63	InterPro	IPR020460	Zinc finger, DksA/TraR C4-type, bacteria
5	76	ProSiteProfiles	PS51128	Prokaryotic dksA C4-type zinc finger profiles.
5	76	InterPro	IPR000962	Zinc finger, DksA/TraR C4-type
12	66	NCBIfam	TIGR02419	phage/conjugal plasmid C-4 type zinc finger protein, TraR family
12	66	InterPro	IPR012783	Zinc finger, C4 DksA/TraR-type
6	76	Gene3D	G3DSA:1.20.120.910	-
39	63	ProSitePatterns	PS01102	Prokaryotic dksA C4-type zinc finger.
39	63	InterPro	IPR020458	Zinc finger, DksA/TraR C4-type conserved site
1	79	PANTHER	PTHR38777	FELS-2 PROPHAGE PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold DB PA4870	AlphaFold DB	—	—	full sequence	—	Viewing

Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.71

Show in viewer