Protein profile

PA4890

transcriptional regulator

Genome: NC_002516.2

Gene: PA4890 desT Structure source: Experimental + AlphaFold UniProt Q9HUS3
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Amino acids 209
Annotations 6
Features 10
PDB binders 2
Druggability 0.924

Overview

Basic information about this protein and its source genome.

Accession
PA4890
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4890 desT
Status
annotated
Amino acids
209
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0045922 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0045922 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
17 62 Pfam PF00440 Bacterial regulatory proteins, tetR family
17 62 InterPro IPR001647 DNA-binding HTH domain, TetR-type
3 207 PANTHER PTHR47752 HTH-TYPE TRANSCRIPTIONAL REPRESSOR FABR
1 53 Gene3D G3DSA:1.10.10.60 -
10 71 ProSiteProfiles PS50977 TetR-type HTH domain profile.
10 71 InterPro IPR001647 DNA-binding HTH domain, TetR-type
2 78 SUPERFAMILY SSF46689 Homeodomain-like
2 78 InterPro IPR009057 Homeobox-like domain superfamily
54 209 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
1 53 FunFam G3DSA:1.10.10.60:FF:000034 HTH-type transcriptional repressor FabR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3LSJ
X-ray 2.30 Å A,B
100.0% 1-209
PDBe RCSB PDBj File
Viewing
PDB 3LSR
X-ray 2.55 Å A
100.0% 1-209
PDBe RCSB PDBj File
Loaded
PDB 3LSP
X-ray 2.66 Å A
100.0% 1-209
PDBe RCSB PDBj File
Loaded
AlphaFold PA4890
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.924
2 0.672

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 34.07 0.949
2 2.96 0.096
3 1.24 0.012
4 1.01 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
OLA
3LSP 2.66 Å Open crystal
282.5 Da LogP 6.11 TPSA 37.3 1 viol. ✓ Clean CCCCCCCC\C=C/CCCCCCCC(=O)O
PLM
3LSJ 2.30 Å Open crystal
256.4 Da LogP 5.55 TPSA 37.3 1 viol. ✓ Clean CCCCCCCCCCCCCCCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.