Protein profile

PA4892

urease accessory protein UreF

Genome: NC_002516.2

Gene: PA4892 ureF Structure source: AlphaFold UniProt Q9HUS1
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Amino acids 223
Annotations 5
Features 9
PDB binders 0
Druggability 0.856

Overview

Basic information about this protein and its source genome.

Accession
PA4892
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4892 ureF
Status
annotated
Amino acids
223
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016151 Binding to a nickel (Ni) cation. GO:0018237 Increases the activity of urease by promoting the incorporation of nickel into the active site. GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.856
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0018237 Increases the activity of urease by promoting the incorporation of nickel into the active site.
  • GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 213 Gene3D G3DSA:1.10.4190.10 Urease accessory protein UreF
1 213 InterPro IPR038277 UreF domain superfamily
1 223 PIRSF PIRSF009467 Urease_acces_UreF
1 223 InterPro IPR002639 Urease accessory protein UreF
4 223 PANTHER PTHR33620 UREASE ACCESSORY PROTEIN F
3 223 Hamap MF_01385 Urease accessory protein UreF [ureF].
3 223 InterPro IPR002639 Urease accessory protein UreF
35 181 Pfam PF01730 UreF
35 181 InterPro IPR002639 Urease accessory protein UreF

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4892
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.856