Protein profile

PA4895

transmembrane sensor

Genome: NC_002516.2

Gene: PA4895 Structure source: AlphaFold UniProt Q9HUR8
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Amino acids 340
Annotations 1
Features 16
PDB binders 0
Druggability 0.772

Overview

Basic information about this protein and its source genome.

Accession
PA4895
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4895
Status
annotated
Amino acids
340
Structure source
AlphaFold
GO
GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.772
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
33 74 Pfam PF16220 Domain of unknown function (DUF4880)
33 74 InterPro IPR032623 FecR, N-terminal
131 226 Pfam PF04773 FecR protein
131 226 InterPro IPR006860 FecR protein
1 25 MobiDBLite mobidb-lite consensus disorder prediction
119 262 FunFam G3DSA:2.60.120.1440:FF:000002 Probable transmembrane sensor
267 340 Gene3D G3DSA:3.55.50.30 -
125 262 Gene3D G3DSA:2.60.120.1440 -
100 119 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 99 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
120 340 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
100 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 340 PIRSF PIRSF018266 FecR
21 340 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component
27 339 PANTHER PTHR30273 PERIPLASMIC SIGNAL SENSOR AND SIGMA FACTOR ACTIVATOR FECR-RELATED
27 339 InterPro IPR012373 Fe(2+)-dicitrate sensor, transmembrane component

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4895
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.772
3 0.639