Protein profile

PA4913

ABC transporter

Genome: NC_002516.2

Gene: PA4913 Structure source: AlphaFold UniProt Q9HUQ0
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Amino acids 374
Annotations 5
Features 26
PDB binders 1
Druggability 0.386

Overview

Basic information about this protein and its source genome.

Accession
PA4913
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4913
Status
annotated
Amino acids
374
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015818 The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015820 The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015829 The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.386
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0015818 The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015820 The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015829 The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
148 278 Gene3D G3DSA:3.40.50.2300 -
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
22 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
28 374 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28 371 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
28 371 InterPro IPR028082 Periplasmic binding protein-like I
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
29 45 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
29 45 InterPro IPR000709 Leu/Ile/Val-binding protein
51 67 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
51 67 InterPro IPR000709 Leu/Ile/Val-binding protein
283 296 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
283 296 InterPro IPR000709 Leu/Ile/Val-binding protein
70 88 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
70 88 InterPro IPR000709 Leu/Ile/Val-binding protein
334 349 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
334 349 InterPro IPR000709 Leu/Ile/Val-binding protein
36 353 Gene3D G3DSA:3.40.50.2300 -
29 369 Pfam PF13458 Periplasmic binding protein
29 369 InterPro IPR028081 Leucine-binding protein domain
30 364 CDD cd06342 PBP1_ABC_LIVBP-like
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 373 PANTHER PTHR47151 LEU/ILE/VAL-BINDING ABC TRANSPORTER SUBUNIT
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 27 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4913
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.386

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ABU
3IP9
Q7CX36 103.1 Da LogP -0.19 TPSA 63.3 ✓ Ro5 ✓ Clean C(CC(=O)O)CN

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.