Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4915
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4915
Status: annotated
Amino acids: 541
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.9

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records

Show feature table

Start	End	DB	Term	Name
32	189	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
269	505	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
269	505	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
208	258	Pfam	PF00672	HAMP domain
208	258	InterPro	IPR003660	HAMP domain
6	184	Pfam	PF12729	Four helix bundle sensory module for signal transduction
6	184	InterPro	IPR024478	Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain
329	505	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
329	505	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
306	505	CDD	cd11386	MCP_signal
187	207	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
187	207	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
406	435	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
406	435	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
7	32	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
7	32	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
377	404	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
377	404	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
173	270	Gene3D	G3DSA:6.10.340.10	-
232	541	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
214	258	CDD	cd06225	HAMP
189	211	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
11	539	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
290	541	Gene3D	G3DSA:1.10.287.950	-
211	264	ProSiteProfiles	PS50885	HAMP domain profile.
211	264	InterPro	IPR003660	HAMP domain
1	29	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
210	541	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
190	209	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
279	540	SMART	SM00283	MA_2
279	540	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
211	264	SMART	SM00304	HAMP_11
12	31	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
211	541	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
1	11	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4915	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.9
3				0.763
1				0.421

PA4915