Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4919
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4919 pncB1
Status: annotated
Amino acids: 399
Structure source: AlphaFold

EC

6.3.4.21

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516 Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355 The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. GO:0009435 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.638

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

6.3.4.21

Gene Ontology (GO)

4

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0004516 Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate.
GO:0034355 The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis.
GO:0009435 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
12	380	CDD	cd01401	PncB_like
12	380	InterPro	IPR006406	Nicotinate phosphoribosyltransferase
1	383	PIRSF	PIRSF000484	NAPRT
1	383	InterPro	IPR007229	Nicotinate phosphoribosyltransferase family
5	139	SUPERFAMILY	SSF54675	Nicotinate/Quinolinate PRTase N-terminal domain-like
122	397	SUPERFAMILY	SSF51690	Nicotinate/Quinolinate PRTase C-terminal domain-like
122	397	InterPro	IPR036068	Nicotinate phosphoribosyltransferase-like, C-terminal
3	399	FunFam	G3DSA:3.20.140.10:FF:000001	Nicotinate phosphoribosyltransferase
7	399	Hamap	MF_00570	Nicotinate phosphoribosyltransferase [pncB].
7	399	InterPro	IPR006406	Nicotinate phosphoribosyltransferase
10	398	NCBIfam	TIGR01514	nicotinate phosphoribosyltransferase
10	398	InterPro	IPR006406	Nicotinate phosphoribosyltransferase
9	391	PANTHER	PTHR11098	NICOTINATE PHOSPHORIBOSYLTRANSFERASE
9	391	InterPro	IPR007229	Nicotinate phosphoribosyltransferase family
171	398	Pfam	PF04095	Nicotinate phosphoribosyltransferase (NAPRTase) family
171	398	InterPro	IPR041525	Nicotinate/nicotinamide phosphoribosyltransferase
1	399	Gene3D	G3DSA:3.20.140.10	nicotinate phosphoribosyltransferase
15	132	Pfam	PF17767	Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain
15	132	InterPro	IPR040727	Nicotinate phosphoribosyltransferase, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4919	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.638

PA4919