Protein profile

PA4923

hypothetical protein

Genome: NC_002516.2

Gene: PA4923 Structure source: Experimental + AlphaFold UniProt P48636
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Amino acids 195
Annotations 8
Features 8
PDB binders 2
Druggability 0.835

Overview

Basic information about this protein and its source genome.

Accession
PA4923
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4923
Status
annotated
Amino acids
195
Structure source
Experimental + AlphaFold
EC
3.2.2.n1 3.2.2.4
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714 Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0102682 Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate. GO:0016799 Catalysis of the hydrolysis of any N-glycosyl bond. GO:0009691 The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 6 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008714 Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine.
  • GO:0102682 Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate.
  • GO:0016799 Catalysis of the hydrolysis of any N-glycosyl bond.
  • GO:0009691 The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
4 184 PANTHER PTHR31223 LOG FAMILY PROTEIN YJL055W
5 179 NCBIfam TIGR00730 Rossman fold protein, TIGR00730 family
5 179 InterPro IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG
2 180 SUPERFAMILY SSF102405 MCP/YpsA-like
3 192 FunFam G3DSA:3.40.50.450:FF:000012 LOG family protein YvdD
1 186 Gene3D G3DSA:3.40.50.450 -
48 177 Pfam PF03641 Possible lysine decarboxylase
48 177 InterPro IPR031100 LOG family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5ZBJ
X-ray 1.89 Å A
100.0% 1-195
PDBe RCSB PDBj File
Viewing
PDB 5ZBK
X-ray 2.30 Å A
100.0% 1-195
PDBe RCSB PDBj File
Loaded
AlphaFold PA4923
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.268
4 0.252

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.05 0.637
2 6.49 0.328

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

17 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
5ZI9
Q9FBL8 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
TAR
5AJT
M1VUY5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.