Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4924
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4924
Status: annotated
Amino acids: 231
Structure source: AlphaFold

GO

GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.954

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
131	215	CDD	cd12797	M23_peptidase
94	226	PANTHER	PTHR21666	PEPTIDASE-RELATED
20	231	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34	78	ProSiteProfiles	PS51782	LysM domain profile.
34	78	InterPro	IPR018392	LysM domain
1	21	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	19	SignalP_EUK	SignalP-noTM	SignalP-noTM
34	74	FunFam	G3DSA:3.10.350.10:FF:000006	YgeR family lipoprotein
77	229	Gene3D	G3DSA:2.70.70.10	Glucose Permease (Domain IIA)
77	229	InterPro	IPR011055	Duplicated hybrid motif
87	106	MobiDBLite	mobidb-lite	consensus disorder prediction
36	77	CDD	cd00118	LysM
36	77	InterPro	IPR018392	LysM domain
36	76	Pfam	PF01476	LysM domain
36	76	InterPro	IPR018392	LysM domain
87	229	FunFam	G3DSA:2.70.70.10:FF:000010	M23 family peptidase
131	224	Pfam	PF01551	Peptidase family M23
131	224	InterPro	IPR016047	Peptidase M23
35	76	Gene3D	G3DSA:3.10.350.10	LysM domain
35	76	InterPro	IPR036779	LysM domain superfamily
35	79	SMART	SM00257	LysM_2
35	79	InterPro	IPR018392	LysM domain
1	21	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	4	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
5	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	17	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
36	228	SUPERFAMILY	SSF51261	Duplicated hybrid motif
36	228	InterPro	IPR011055	Duplicated hybrid motif
15	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4924	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.954

PA4924