Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4928
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4928
Status: annotated
Amino acids: 747
Structure source: AlphaFold

GO

GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005506 Binding to an iron (Fe) ion. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.502

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005506 Binding to an iron (Fe) ion.
GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
1	691	PANTHER	PTHR32331	UPF0313 PROTEIN YGIQ
1	691	InterPro	IPR022946	Uncharacterised protein family UPF0313
379	584	Pfam	PF04055	Radical SAM superfamily
379	584	InterPro	IPR007197	Radical SAM
680	694	MobiDBLite	mobidb-lite	consensus disorder prediction
8	692	SFLD	SFLDG01069	UPF0313
8	692	InterPro	IPR022946	Uncharacterised protein family UPF0313
8	692	SFLD	SFLDS00029	Radical SAM
8	692	InterPro	IPR007197	Radical SAM
374	638	Gene3D	G3DSA:3.80.30.20	tm_1862 like domain
374	638	InterPro	IPR023404	Radical SAM, alpha/beta horseshoe
375	628	SMART	SM00729	MiaB
375	628	InterPro	IPR006638	Elp3/MiaA/NifB-like, radical SAM core domain
371	640	ProSiteProfiles	PS51918	Radical SAM core domain profile.
371	640	InterPro	IPR007197	Radical SAM
379	399	ProSitePatterns	PS01278	Methylthiotransferase radical SAM domain signature.
379	399	InterPro	IPR020612	Methylthiotransferase, conserved site
23	378	Pfam	PF08497	Radical SAM N-terminal
23	378	InterPro	IPR013704	UPF0313, N-terminal
672	747	MobiDBLite	mobidb-lite	consensus disorder prediction
370	620	SUPERFAMILY	SSF102114	Radical SAM enzymes
23	645	Hamap	MF_01251	UPF0313 protein YgiQ [ygiQ].
23	645	InterPro	IPR022946	Uncharacterised protein family UPF0313
23	643	NCBIfam	TIGR03904	YgiQ family radical SAM protein
23	643	InterPro	IPR022946	Uncharacterised protein family UPF0313
593	734	Pfam	PF11842	Domain of unknown function (DUF3362)
593	734	InterPro	IPR024560	UPF0313, C-terminal
47	606	SFLD	SFLDG01082	B12-binding domain containing

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4928	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.502
8				0.459
4				0.388

PA4928