Overview
Basic information about this protein and its source genome.
- Accession
- PA4953
- Gene
- PA4953 motB
- Status
- annotated
- Amino acids
- 347
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Unknown
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
3- GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.
- GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
- GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 46 | 347 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 7 | 284 | PANTHER | PTHR30329 | STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX |
| 287 | 329 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 75 | 120 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 15 | 63 | Pfam | PF13677 | Membrane MotB of proton-channel complex MotA/MotB |
| 15 | 63 | InterPro | IPR025713 | Motility protein B-like, N-terminal domain |
| 1 | 25 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 26 | 45 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 21 | 43 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 85 | 118 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 171 | 277 | SUPERFAMILY | SSF103088 | OmpA-like |
| 171 | 277 | InterPro | IPR036737 | OmpA-like domain superfamily |
| 162 | 281 | ProSiteProfiles | PS51123 | OmpA-like domain profile. |
| 162 | 281 | InterPro | IPR006665 | OmpA-like domain |
| 174 | 265 | Pfam | PF00691 | OmpA family |
| 174 | 265 | InterPro | IPR006665 | OmpA-like domain |
| 107 | 139 | Coils | Coil | Coil |
| 112 | 291 | Gene3D | G3DSA:3.30.1330.60 | - |
| 112 | 291 | InterPro | IPR036737 | OmpA-like domain superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed AlphaFold model PA4953 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA4953
|
AlphaFold | — | — | full sequence | — | Viewing |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
No PDB ligands found through similar proteins.
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC27644247 | 0.618 | 230.3 Da LogP 0.09 TPSA 111.2 | ✓ Ro5 | ✓ Clean |
CCCCNC(=N)NCCC[C@H](N)C(=O)O
|
| ZINC196899382 | 0.588 | 228.2 Da LogP -0.14 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCNC(=O)C(F)(F)F)C(=O)O
|
| ZINC4155291 | 0.583 | 216.2 Da LogP -1.37 TPSA 130.8 | ✓ Ro5 | ✓ Clean |
CC(=O)/N=C(\N)NCCC[C@H](N)C(=O)O
|
| ZINC4155299 | 0.583 | 216.2 Da LogP -1.37 TPSA 130.8 | ✓ Ro5 | ✓ Clean |
CC(=O)/N=C(\N)NCCC[C@@H](N)C(=O)O
|
| ZINC1529718 | 0.571 | 202.3 Da LogP -0.74 TPSA 102.4 | ✓ Ro5 | ✓ Clean |
CN(C)C(=N)NCCC[C@H](N)C(=O)O
|
| ZINC1546170 | 0.571 | 216.3 Da LogP -0.30 TPSA 111.2 | ✓ Ro5 | ✓ Clean |
CCCNC(=N)NCCC[C@H](N)C(=O)O
|
| ZINC2560273 | 0.571 | 202.3 Da LogP -0.69 TPSA 111.2 | ✓ Ro5 | ✓ Clean |
CCNC(=N)NCCC[C@H](N)C(=O)O
|
| ZINC4543782 | 0.571 | 202.3 Da LogP -0.74 TPSA 102.4 | ✓ Ro5 | ✓ Clean |
CN(C)C(=N)NCCC[C@@H](N)C(=O)O
|
| ZINC7997269 | 0.571 | 205.3 Da LogP 0.07 TPSA 99.2 | ✓ Ro5 | ✓ Clean |
CSC(=N)NCCC[C@@H](N)C(=O)O
|
| ZINC144076260 | 0.559 | 232.2 Da LogP -0.84 TPSA 129.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)CC(=O)O)C(=O)O
|
| ZINC218922593 | 0.559 | 204.2 Da LogP -1.32 TPSA 112.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)CO)C(=O)O
|
| ZINC2516116 | 0.559 | 275.3 Da LogP -1.12 TPSA 155.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)CC[C@H](N)C(=O)O)C(=O)O
|
| ZINC4545887 | 0.559 | 275.3 Da LogP -1.12 TPSA 155.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)CC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC4545888 | 0.559 | 275.3 Da LogP -1.12 TPSA 155.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCC(=O)NCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC4545889 | 0.559 | 275.3 Da LogP -1.12 TPSA 155.7 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCNC(=O)CC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC50027904 | 0.559 | 261.3 Da LogP -1.51 TPSA 155.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)C[C@H](N)C(=O)O)C(=O)O
|
| ZINC12503853 | 0.556 | 201.3 Da LogP 0.55 TPSA 99.2 | ✓ Ro5 | ✓ Clean |
CCCC(=N)NCCC[C@H](N)C(=O)O
|
| ZINC1640080 | 0.556 | 232.3 Da LogP 0.70 TPSA 101.6 | ✓ Ro5 | ✓ Clean |
CC(C)(C)OC(=O)NCCC[C@H](N)C(=O)O
|
| ZINC217503161 | 0.556 | 230.3 Da LogP 0.88 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CCCCC(=O)NCCCC[C@H](N)C(=O)O
|
| ZINC2560765 | 0.556 | 232.3 Da LogP 0.70 TPSA 101.6 | ✓ Ro5 | ✓ Clean |
CC(C)(C)OC(=O)NCCC[C@@H](N)C(=O)O
|
| ZINC3055005 | 0.556 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC3055007 | 0.556 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC3055010 | 0.556 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC675038108 | 0.556 | 231.3 Da LogP -1.49 TPSA 123.3 | 1 viol. | ✓ Clean |
CNC(NC)C(=N)NCCC[C@H](N)C(=O)O
|
| ZINC100017163 | 0.553 | 213.3 Da LogP 0.71 TPSA 99.2 | ✓ Ro5 | ✓ Clean |
C/C=C/CC(=N)NCCC[C@H](N)C(=O)O
|
| ZINC19796052 | 0.553 | 219.2 Da LogP -1.73 TPSA 156.9 | ✓ Ro5 | ✓ Clean |
N/C(=N\[N+](=O)[O-])NCCC[C@H](N)C(=O)O
|
| ZINC21982226 | 0.553 | 219.2 Da LogP -1.73 TPSA 156.9 | ✓ Ro5 | ✓ Clean |
N/C(=N\[N+](=O)[O-])NCCC[C@@H](N)C(=O)O
|
| ZINC5113209 | 0.548 | 275.3 Da LogP -0.26 TPSA 138.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC13545298 | 0.543 | 202.3 Da LogP 0.09 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CCC(=O)NCCCC[C@H](N)C(=O)O
|
| ZINC216616240 | 0.543 | 430.5 Da LogP 0.72 TPSA 184.8 | 1 viol. | ✓ Clean |
N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](N)C(=O)…
|
| ZINC6360447 | 0.543 | 222.3 Da LogP 0.37 TPSA 75.3 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCNC(=S)S)C(=O)O
|
| ZINC1530092 | 0.541 | 254.2 Da LogP -1.61 TPSA 168.8 | 1 viol. | ✓ Clean |
N=C(NCCC[C@H](N)C(=O)O)NP(=O)(O)O
|
| ZINC230402790 | 0.541 | 214.3 Da LogP 0.26 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
C/C=C/C(=O)NCCCC[C@H](N)C(=O)O
|
| ZINC237993466 | 0.541 | 214.3 Da LogP 0.26 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
C/C=C/C(=O)NCCCC[C@@H](N)C(=O)O
|
| ZINC2509855 | 0.541 | 216.2 Da LogP 0.09 TPSA 101.6 | ✓ Ro5 | ✓ Clean |
C=CCOC(=O)NCCC[C@H](N)C(=O)O
|
| ZINC5965908 | 0.541 | 202.3 Da LogP -1.03 TPSA 99.7 | ✓ Ro5 | ✓ Clean |
C/N=C(\NC)NCCC[C@H](N)C(=O)O
|
| ZINC98044182 | 0.541 | 216.2 Da LogP 0.09 TPSA 101.6 | ✓ Ro5 | ✓ Clean |
C=CCOC(=O)NCCC[C@@H](N)C(=O)O
|
| ZINC1555366 | 0.536 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1555367 | 0.536 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1555369 | 0.536 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720127 | 0.536 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1720128 | 0.536 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720130 | 0.536 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1608689 | 0.528 | 202.3 Da LogP 0.09 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CCCCNC(=O)CC[C@H](N)C(=O)O
|
| ZINC1737898 | 0.528 | 245.3 Da LogP -0.33 TPSA 118.4 | ✓ Ro5 | ✓ Clean |
CC(C)[C@@H](N)C(=O)NCCCC[C@@H](N)C(=O)O
|
| ZINC2027403 | 0.528 | 200.2 Da LogP -0.13 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
C=CC(=O)NCCCC[C@H](N)C(=O)O
|
| ZINC2045835 | 0.528 | 202.3 Da LogP 0.09 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CCCCNC(=O)CC[C@@H](N)C(=O)O
|
| ZINC2384794 | 0.528 | 242.2 Da LogP 0.25 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)O
|
| ZINC6292525 | 0.528 | 242.2 Da LogP 0.25 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCNC(=O)C(F)(F)F)C(=O)O
|
| ZINC71754172 | 0.528 | 246.3 Da LogP -0.45 TPSA 129.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCNC(=O)CCC(=O)O)C(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.